Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 5/20 | 0.46 |
| ▸ | CCR8 | P51685 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CCR5 | P51681 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16502608 | 0.86 | SLC40A1 (0.50) | CCR1CCR8LMNACCR5MMP2 | |
| SCHEMBL7918689 | 0.80 | KDM4E (0.45) | CCR1CCR8LMNACCR5SMN1; SMN2 | |
| SCHEMBL16503471 | 0.80 | DOT1L (0.39) | CCR1CCR8LMNACCR5MMP2 | |
| SCHEMBL16502605 | 0.79 | ALOX15 (0.56) | LMNASMN1; SMN2KDM4ETP53MAPT | |
| SCHEMBL7919781 | 0.78 | TNF (0.54) | KDM4ECYP3A4CYP2D6HDAC6 | |
| SCHEMBL16503545 | 0.78 | LMNA (0.40) | CCR1CCR8LMNACCR5MMP2 | |
| SCHEMBL7917731 | 0.77 | TNF (0.49) | LMNASMN1; SMN2KDM4ETP53CYP3A4 | |
| SCHEMBL7913890 | 0.77 | KDM4E (0.38) | KDM4EMAPTHTTHDAC1F2 | |
| SCHEMBL16502784 | 0.77 | SLC9A1 (0.48) | ADRA1APRSS1 | |
| SCHEMBL7917427 | 0.76 | F2 (0.41) | LMNASMN1; SMN2KDM4EMAPTHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |