SCHEMBL7919571

SCHEMBL7919571

Cc1cc(NN)cc(Cl)c1C(C#N)c1ccc(Cl)nc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.36
GAA P10253 4/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
LMNA P02545 1/20 0.32
MEN1 O00255 1/20 0.31
NR1I2 O75469 1/20 0.31
KMT2A Q03164 1/20 0.31
PKM P14618 1/20 0.31
KCNQ3 O43525 1/20 0.31
KCNQ2 O43526 1/20 0.31
S1PR3 Q99500 2/20 0.31
POLB P06746 1/20 0.31
SRC P12931 1/20 0.30
CYP3A4 P08684 2/20 0.30
CYP2D6 P10635 2/20 0.30
SLC6A2 P23975 2/20 0.30
SLC6A4 P31645 2/20 0.30
SLC6A3 Q01959 2/20 0.30
KCNH2 Q12809 1/20 0.30
S1PR1 P21453 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7917739 0.83 MEN1 (0.39) ALDH1A1GAAL3MBTL1LMNAMEN1
SCHEMBL7922549 0.76
SCHEMBL7843623 0.73 MEN1 (0.45) ALDH1A1GAAL3MBTL1LMNAMEN1
SCHEMBL7837943 0.72 SLC6A3 (0.41) GAAMEN1NR1I2KMT2APOLB
Hydrochloric Acid SCHEMBL28619070 0.72 MEN1 (0.44) ALDH1A1GAAL3MBTL1LMNAMEN1
SCHEMBL7917025 0.71 MEN1 (0.38) MEN1NR1I2KMT2A
SCHEMBL10420876 0.65 ALDH1A1 (0.41) ALDH1A1GAAL3MBTL1LMNAMEN1
SCHEMBL7917050 0.65 ADRB2 (0.34) ALDH1A1GAALMNAS1PR3CYP3A4
SCHEMBL3962576 0.64 RPS6KB1 (0.39) ALDH1A1GAAL3MBTL1LMNAS1PR3
SCHEMBL3077972 0.64 ALDH1A1 (0.39) ALDH1A1GAALMNAS1PR3CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211178-B1 ANTIPROTOZOA AGENTS FOR COCCIDIOIDES; CYCLIZATION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US disclosed
US-5994355-A ANTIPROTOZOA AGENTS, PARASITICIDE; VETERINARY MEDICINE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-11-30 US disclosed
EP-0648760-B1 Triazine derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-01-27 EP disclosed
EP-0648760-A2 Triazine derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-04-19 EP disclosed