Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RUVBL1 | Q9Y265 | 4/20 | 0.59 |
| ▸ | CDK4 | P11802 | 6/20 | 0.58 |
| ▸ | CCND1 | P24385 | 6/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28072305 | 0.83 | RUVBL1 (0.65) | RUVBL1HDAC8HDAC3HDAC1HDAC6 | |
| SCHEMBL11860142 | 0.83 | RUVBL1 (0.65) | RUVBL1HDAC8HDAC3HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL19748758 | 0.82 | RUVBL1 (0.73) | RUVBL1HDAC8HDAC3HDAC1HDAC6 | |
| SCHEMBL9609465 | 0.82 | MEN1 (0.71) | RUVBL1HDAC8HDAC3HDAC1HDAC6 | |
| SCHEMBL30767397 | 0.82 | MEN1 (0.71) | RUVBL1HDAC8HDAC3HDAC1HDAC6 | |
| SCHEMBL9610738 | 0.82 | MEN1 (0.71) | RUVBL1HDAC8HDAC3HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL19747056 | 0.81 | MEN1 (0.69) | RUVBL1HDAC8HDAC3HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL21082966 | 0.81 | MEN1 (0.69) | RUVBL1HDAC8HDAC3HDAC1HDAC6 | |
| SCHEMBL4523817 | 0.80 | RUVBL1 (0.67) | RUVBL1HDAC8HDAC3HDAC1HDAC6 | |
| SCHEMBL8252240 | 0.79 | RUVBL1 (0.70) | RUVBL1HDAC8HDAC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228985-B1 | COMPOUNDS THAT INHIBIT INTERACTION OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR WITH UROKINASE-TYPE PLASMINOGEN RECEPTOR; ANTITUMOR AGENTS; ANTIMETASTASIS AGENTS; ANTIARTHRITIC AGENTS FOR RHEUMATOID ARTHRITIS | SCHERING CORPORATION | 2001-05-08 | — | — | US | disclosed |