Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | GAPDH | P04406 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.34 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7923350 | 1.00 | LMNA (0.39) | LMNATSHRSMN1; SMN2OPRM1FDPS | |
| SCHEMBL20143287 | 0.98 | LMNA (0.43) | LMNATSHRSMN1; SMN2FDPSMAPT | |
| SCHEMBL20143282 | 0.98 | LMNA (0.43) | LMNATSHRSMN1; SMN2FDPSMAPT | |
| SCHEMBL28690695 | 0.93 | TSHR (0.44) | LMNATSHRSMN1; SMN2FDPSCA1 | |
| SCHEMBL8601150 | 0.91 | TSHR (0.45) | LMNATSHRSMN1; SMN2OPRM1FDPS | |
| SCHEMBL8182070 | 0.88 | TSHR (0.41) | TSHRSMN1; SMN2FDPSCA1 | |
| SCHEMBL28753432 | 0.87 | SPHK1 (0.40) | LMNAOPRM1MAPTGPR84SPHK1 | |
| SCHEMBL8902146 | 0.84 | TSHR (0.52) | TSHRSMN1; SMN2FDPSCA1 | |
| SCHEMBL8902150 | 0.84 | TSHR (0.52) | TSHRSMN1; SMN2FDPSCA1 | |
| SCHEMBL28181292 | 0.82 | TSHR (0.50) | TSHRSMN1; SMN2FDPSCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174898-B1 | TREATING FILARIAE IN LYMPHATIC SYSTEM BY ADMINISTERING N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS IN WHICH A SUBSTITUTED ALKYL CHAIN FORMS PART OF N-SUBSTITUENT AND SALTS | NOVO NORDISK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| EP-0858339-A1 | A METHOD OF TREATING FILARIAE | NOVO NORDISK A/S (DK) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997017073-A1 | A METHOD OF TREATING FILARIAE | NOVO NORDISK A/S (DK) | 1997-05-15 | — | — | WO | disclosed |
| EP-0342635-B1 | Azacyclic carboxylic acid derivatives, their preparation and use | NOVO NORDISK AS (DK) | 1994-08-17 | — | — | EP | disclosed |
| US-5231106-A | Nervous sytem disorders; blocking og gamma aminobutyric acid | NOVO NORDISK A/S (DK) | 1993-07-27 | — | — | US | disclosed |
| US-5229404-A | Inhibitors of gamma-aminobutyric acid re-uptake, antiepileptic agents | NOVO NORDISK A/S (DK) | 1993-07-20 | — | — | US | disclosed |
| US-5214054-A | Gamma-aminobutyric acid re-uptake inhibitors, antiepileptic, analgesics, anxiolytics | NOVO NORDISK A/S (DK) | 1993-05-25 | — | — | US | disclosed |
| CN-1018829-B | PROCESS FOR THE PREPARATION OF NOVEL ALKYLENEDIAMINE DERIVATIVES | NIPPON CHEMIPHAR CO (JP) | 1992-10-28 | — | — | CN | disclosed |
| US-5039685-A | Nervous system disorders | NOVO NORDISK A/S (DK) | 1991-08-13 | — | — | US | disclosed |
| EP-0342635-A1 | Azacyclic carboxylic acid derivatives, their preparation and use | NOVO NORDISK A/S (DK) | 1989-11-23 | — | — | EP | disclosed |
| CN-87101762-A | The method for preparing novel alkylenediamine derivatives | — | 1987-10-07 | — | — | CN | disclosed |