Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.39 |
| ▸ | FDPS | P14324 | 3/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.38 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADH1B | P00325 | 1/20 | 0.36 |
| ▸ | ADH1C | P00326 | 1/20 | 0.36 |
| ▸ | ADH1A | P07327 | 1/20 | 0.36 |
| ▸ | ADH4 | P08319 | 1/20 | 0.36 |
| ▸ | ADH7 | P40394 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20143287 | 1.00 | LMNA (0.43) | LMNAGPR84FDPSSPHK1FFAR1 | |
| SCHEMBL7923350 | 0.98 | LMNA (0.39) | LMNAGPR84FDPSSPHK1FFAR1 | |
| SCHEMBL7923353 | 0.98 | LMNA (0.39) | LMNAGPR84FDPSSPHK1FFAR1 | |
| SCHEMBL28690695 | 0.91 | TSHR (0.44) | LMNAFDPSEP300DNM1TSHR | |
| SCHEMBL8601150 | 0.89 | TSHR (0.45) | LMNAGPR84FDPSSPHK1FFAR1 | |
| SCHEMBL28753432 | 0.89 | SPHK1 (0.40) | LMNAGPR84SPHK1FFAR1MAPT | |
| SCHEMBL8182070 | 0.86 | TSHR (0.41) | FDPSDNM1TSHRSMN1; SMN2 | |
| SCHEMBL6503063 | 0.83 | FAAH (0.41) | LMNAFFAR1MAPTPPARDGMNN | |
| SCHEMBL8902146 | 0.82 | TSHR (0.52) | FDPSDNM1TSHRSMN1; SMN2 | |
| SCHEMBL8902150 | 0.82 | TSHR (0.52) | FDPSDNM1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969679-B2 | Anti-proliferative compounds and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-15 | — | — | US | disclosed |