Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
| ▸ | MMP13 | P45452 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | AURKAIP1 | Q9NWT8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360052 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2NAMPTLMNAHTTALDH1A1 | |
| SCHEMBL7928510 | 0.78 | LMNA (0.50) | SMN1; SMN2LMNAHTTALDH1A1MMP9 | |
| SCHEMBL7200356 | 0.75 | KMT2A (0.55) | SMN1; SMN2NAMPTLMNAHTTALDH1A1 | |
| SCHEMBL11576737 | 0.73 | CA12 (0.59) | SMN1; SMN2NAMPTLMNAHTTALDH1A1 | |
| SCHEMBL19264967 | 0.73 | SIGMAR1 (0.57) | SMN1; SMN2NAMPTALDH1A1MMP9MMP13 | |
| SCHEMBL2414975 | 0.73 | SIGMAR1 (0.57) | SMN1; SMN2NAMPTLMNAALDH1A1NEK1 | |
| SCHEMBL5722103 | 0.73 | KMT2A (0.53) | NAMPTLMNAALDH1A1NEK1KMT2A | |
| SCHEMBL10282720 | 0.72 | KMT2A (0.52) | SMN1; SMN2NAMPTLMNAALDH1A1SLC6A4 | |
| SCHEMBL13188184 | 0.72 | NAPRT (0.50) | NAMPTALDH1A1NEK1KMT2AKDM4E | |
| SCHEMBL20388961 | 0.71 | NAMPT (1.00) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | disclosed |