Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | MMP13 | P45452 | 4/20 | 0.45 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 7/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 4/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7924869 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2MMP13MMP9LMNAHTT | |
| SCHEMBL7924925 | 0.77 | MMP1 (0.48) | SMN1; SMN2MMP13MMP9ALDH1A1MMP1 | |
| SCHEMBL7928510 | 0.72 | LMNA (0.50) | SMN1; SMN2MMP13MMP9LMNAHTT | |
| SCHEMBL7924930 | 0.68 | MMP1 (0.37) | SMN1; SMN2MMP13MMP9MMP1 | |
| SCHEMBL7924934 | 0.68 | MMP1 (0.46) | MMP9MMP1MMP2 | |
| SCHEMBL1101042 | 0.67 | LMNA (0.40) | SMN1; SMN2MMP13MMP9LMNAHTT | |
| SCHEMBL1108565 | 0.67 | LMNA (0.40) | SMN1; SMN2MMP13MMP9LMNAHTT | |
| SCHEMBL7512941 | 0.66 | PTGS2 (0.55) | SMN1; SMN2MMP13MMP9LMNAHTT | |
| SCHEMBL6338957 | 0.66 | MMP1 (0.53) | SMN1; SMN2MMP13MMP9LMNAHTT | |
| SCHEMBL7533681 | 0.65 | MMP9 (0.53) | MMP13MMP9MMP1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000044712-A1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | claimed |
| WO-2000044712-A1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | disclosed |