Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673729 | 0.81 | ALDH1A1 (0.56) | LMNAKDM4EHSD17B10ALDH1A1GAA | |
| SCHEMBL6501728 | 0.80 | KMT2A (0.59) | LMNAALDH1A1GAAALOX15MAPK1 | |
| SCHEMBL2332913 | 0.79 | ADRB2 (0.65) | ALDH1A1GAAALOX15TSHRTDP1 | |
| SCHEMBL6500736 | 0.79 | KMT2A (0.56) | KDM4EALDH1A1GAASMN1; SMN2ALOX15 | |
| SCHEMBL11482764 | 0.78 | KMT2A (0.53) | LMNAALDH1A1GAASMN1; SMN2ALOX15 | |
| SCHEMBL7924869 | 0.78 | SMN1; SMN2 (0.60) | LMNAKDM4EHSD17B10MMP9MMP13 | |
| SCHEMBL26247562 | 0.75 | MAPT (0.61) | LMNAKDM4EALDH1A1GAAALOX15 | |
| SCHEMBL7928511 | 0.74 | MMP1 (0.51) | LMNAMMP9MMP13MMP1ALDH1A1 | |
| SCHEMBL7360052 | 0.72 | SMN1; SMN2 (0.47) | LMNAKDM4EHSD17B10MMP9MMP13 | |
| SCHEMBL7193091 | 0.71 | ALDH1A1 (0.43) | LMNAKDM4EHSD17B10ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | disclosed |