Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592225 | 0.98 | EPHX2 (0.51) | EPHX2ALDH1A1HPGDPOLBHDAC8 | |
| Hydrochloric Acid SCHEMBL28539557 | 0.98 | EPHX2 (0.48) | EPHX2ALDH1A1HPGDPOLBHDAC8 | |
| SCHEMBL11244833 | 0.91 | HDAC8 (0.52) | EPHX2ALDH1A1HPGDPOLBHDAC8 | |
| SCHEMBL9349123 | 0.90 | EPHX2 (0.47) | EPHX2ALDH1A1HPGDPOLBHDAC8 | |
| SCHEMBL14084928 | 0.86 | EPHX2 (0.47) | EPHX2ALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL13779902 | 0.86 | EPHX2 (0.50) | EPHX2ALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL9348792 | 0.79 | EPHX2 (0.40) | EPHX2ALDH1A1HPGDPOLBMEN1 | |
| Hydrochloric Acid SCHEMBL3169421 | 0.79 | CHRNB2 (0.48) | EPHX2ALDH1A1HPGDPOLB | |
| SCHEMBL7791787 | 0.76 | PADI1 (0.46) | EPHX2ALDH1A1POLBHDAC8HDAC6 | |
| SCHEMBL28991011 | 0.76 | HDAC8 (0.45) | EPHX2ALDH1A1HPGDHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499144-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-09-19 | — | — | EP | claimed |
| EP-2499129-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-09-19 | — | — | EP | claimed |
| US-20120095005-A1 | Fused Bicyclic Pyrazole Derivatives As Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2012-04-19 | — | — | US | claimed |
| EP-2432784-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-03-28 | — | — | EP | claimed |
| WO-2011058108-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | claimed |
| WO-2011058110-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | claimed |
| WO-2010133836-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-11-25 | — | — | WO | claimed |
| CN-107912040-B | Pyrrolidine amide compounds as histone demethylase inhibitors | 基因泰克公司 | 2021-04-06 | — | — | CN | disclosed |
| CN-103889226-B | 1, 3-diaryl substituted heterocyclic insecticides | 纳幕尔杜邦公司 | 2017-02-15 | — | — | CN | disclosed |
| US-9113631-B2 | 1,3-diaryl-substituted heterocyclic pesticides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-08-25 | — | — | US | disclosed |
| US-20140249025-A1 | 1,3-DIARYL-SUBSTITUTED HETEROCYCLIC PESTICIDES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2014-09-04 | — | — | US | disclosed |
| EP-2770831-A1 | 1,3-DIARYL-SUBSTITUTED HETEROCYCLIC PESTICIDES | E. I. Du Pont de Nemours and Company (US) | 2014-09-03 | — | — | EP | disclosed |
| CN-103889226-A | 1, 3-diaryl substituted heterocyclic insecticides | DU PONT | 2014-06-25 | — | — | CN | disclosed |
| EP-2432784-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133836-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-11-25 | — | — | WO | disclosed |
| EP-1943231-A1 | (HETERO)ARYL COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2008057420-A2 | EXTENDED TRITERPENE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-05-15 | — | — | WO | disclosed |
| US-20070111981-A1 | New (hetero)aryl compounds with MCH antagonistic activity and medicaments comprising these compounds | ROTH GERALD J | 2007-05-17 | — | — | US | disclosed |
| WO-2007048802-A1 | (HETERO)ARYL COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-03 | — | — | WO | disclosed |
| US-20060205697-A1 | Novel betulin derivatives, preparation thereof and use thereof | MYREXIS, INC. | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070111981-A1 | New (hetero)aryl compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, GPR119, MCHR2 | EPHX2 1171/4885ALDH1A1 3960/4885HPGD 3220/4885 |
| US-20060205697-A1 | Novel betulin derivatives, preparation thereof and use thereof | BET1, PGGT1B, TMPO | EPHX2 789/4885ALDH1A1 2323/4885HPGD 254/4885 |
| US-20140249025-A1 | 1,3-DIARYL-SUBSTITUTED HETEROCYCLIC PESTICIDES | DDT, CHRM1, CYP1B1 | EPHX2 618/4885ALDH1A1 856/4885HPGD 2404/4885 |
| US-20120095005-A1 | Fused Bicyclic Pyrazole Derivatives As Kinase Inhibitors | PI4KA, PDPK1, PIK3CA | EPHX2 2071/4885ALDH1A1 1059/4885HPGD 1418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.