Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 5/20 | 0.44 |
| ▸ | EDNRA | P25101 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937196 | 0.89 | EDNRB (0.49) | EDNRBEDNRA | |
| SCHEMBL7934373 | 0.85 | ALOX5 (0.41) | EDNRBEDNRASMN1; SMN2NPC1TP53 | |
| SCHEMBL7934306 | 0.82 | EDNRB (0.46) | EDNRBEDNRASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8098308 | 0.79 | EDNRB (0.50) | EDNRBEDNRA | |
| SCHEMBL8109239 | 0.77 | EDNRB (0.57) | EDNRBEDNRA | |
| SCHEMBL1069539 | 0.76 | EDNRB (0.55) | EDNRBEDNRA | |
| SCHEMBL7937232 | 0.75 | KDM4E (0.44) | EDNRBEDNRASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7934325 | 0.73 | MAPT (0.43) | EDNRBEDNRASMN1; SMN2NPC1RAB9A | |
| SCHEMBL8116655 | 0.72 | EDNRB (0.46) | EDNRBEDNRAALOX5 | |
| SCHEMBL8634830 | 0.71 | EDNRB (0.35) | EDNRBEDNRAALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235903-B1 | Method for preparing sulfanyl-type endothelin receptor antagonists | BASF AKTIENGESELLSCHAFT (DE) | 2001-05-22 | — | — | US | disclosed |