Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 14/20 | 0.43 |
| ▸ | MMP2 | P08253 | 9/20 | 0.39 |
| ▸ | MMP1 | P03956 | 8/20 | 0.39 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | MMP16 | P51512 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928474 | 0.77 | MMP13 (0.51) | MMP13MMP2MMP1MMP9MMP3 | |
| SCHEMBL7922816 | 0.75 | MMP13 (0.48) | MMP13MMP2MMP1MMP9MMP3 | |
| SCHEMBL7928380 | 0.73 | MMP13 (0.43) | MMP13MMP2MMP1MMP9MMP3 | |
| SCHEMBL6719195 | 0.64 | LMNA (0.62) | MMP13MMP2MMP1MMP9MMP3 | |
| SCHEMBL1133773 | 0.63 | LMNA (0.59) | MMP13MMP2MMP1MMP9MMP3 | |
| SCHEMBL6267856 | 0.62 | MMP13 (0.56) | MMP13MMP2MMP1MMP9MMP3 | |
| SCHEMBL9351423 | 0.62 | ALOX5 (0.44) | MMP13MMP2MMP9 | |
| SCHEMBL28121991 | 0.62 | HSD11B1 (0.41) | MMP13MMP1 | |
| SCHEMBL569675 | 0.61 | LMNA (0.56) | MMP13MMP2MMP1MMP9MMP3 | |
| SCHEMBL12895710 | 0.60 | SOS1 (0.58) | MMP13MMP2MMP1MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | disclosed |