Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 14/20 | 0.51 |
| ▸ | MMP2 | P08253 | 9/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 9/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7922816 | 0.82 | MMP13 (0.48) | MMP13MMP2MMP3MMP9MMP14 | |
| SCHEMBL7928380 | 0.80 | MMP13 (0.43) | MMP13MMP2MMP3MMP9MMP14 | |
| SCHEMBL7928475 | 0.77 | MMP13 (0.43) | MMP13MMP2MMP3MMP9MMP14 | |
| SCHEMBL9351423 | 0.70 | ALOX5 (0.44) | MMP13MMP2MMP9 | |
| SCHEMBL7924711 | 0.69 | MMP2 (0.63) | MMP13MMP2MMP3MMP9MMP14 | |
| SCHEMBL7922815 | 0.66 | MMP1 (0.59) | MMP13MMP2MMP3MMP9MMP14 | |
| SCHEMBL7360559 | 0.66 | MMP13 (0.62) | MMP13MMP2MMP3MMP9MMP14 | |
| SCHEMBL6719195 | 0.66 | LMNA (0.62) | MMP13MMP2MMP3MMP9MMP14 | |
| SCHEMBL9781099 | 0.65 | ALOX5 (0.48) | MMP13MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL9781097 | 0.65 | ALOX5 (0.48) | MMP13MEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | disclosed |