Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | ABL2 | P42684 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378478 | 0.83 | DHFR (0.39) | RAB9ASMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL3379679 | 0.82 | DHFR (0.38) | RAB9ASMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL3381911 | 0.82 | RAB9A (0.39) | RAB9ASMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL7928989 | 0.80 | PIK3CD (0.38) | — | |
| SCHEMBL7932127 | 0.80 | DYRK3 (0.51) | MAPTADORA2AADORA1PDE4DJAK2 | |
| SCHEMBL7930902 | 0.77 | XPO1 (0.35) | RAB9ASMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL7932092 | 0.76 | KCNQ3 (0.45) | KDRJAK2 | |
| SCHEMBL2919463 | 0.73 | DHFR (0.39) | KMT2ADHFRADORA2AADORA1PTPN11 | |
| SCHEMBL16044758 | 0.73 | PDE4D (0.44) | MAPTDHFRADORA2AADORA1KDR | |
| SCHEMBL7911614 | 0.73 | PDE4D (0.60) | DHFRTDO2PDE4DFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |