Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7932127 | 0.80 | DYRK3 (0.51) | XPO1GPR119DYRK3DYRK1ADYRK2 | |
| SCHEMBL7928993 | 0.77 | RAB9A (0.41) | MAPTSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL7928989 | 0.76 | PIK3CD (0.38) | DYRK3DYRK1ADYRK2DYRK1B | |
| SCHEMBL3380292 | 0.67 | SLC6A9 (0.37) | GPR119CYP2C19HPGDPDE4DJAK2 | |
| SCHEMBL3377566 | 0.67 | DYRK3 (0.50) | XPO1GPR119DYRK3DYRK1ADYRK2 | |
| SCHEMBL7934179 | 0.65 | DYRK3 (0.50) | XPO1DYRK3DYRK1ADYRK2DYRK1B | |
| SCHEMBL7916997 | 0.65 | JAK2 (0.35) | XPO1GPR119DYRK3DYRK1ADYRK2 | |
| SCHEMBL3377711 | 0.64 | KMT2A (0.40) | GPR119MAPTGABRA2GABRB2CYP2C19 | |
| SCHEMBL3380818 | 0.64 | PDE4D (0.40) | GPR119DYRK3DYRK1ADYRK2DYRK1B | |
| SCHEMBL3378344 | 0.62 | ABL1 (0.39) | DYRK3DYRK1ADYRK2DYRK1BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |