Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7931521 | 0.83 | ADORA3 (0.39) | GRM2KDM4EHPGDMAOBLMNA | |
| SCHEMBL7934819 | 0.78 | GRM2 (0.39) | GRM2KDM4EHPGDMAOBLMNA | |
| SCHEMBL3380430 | 0.76 | MAOB (0.38) | KDM4EHPGDMAOBLMNAGAA | |
| SCHEMBL7905671 | 0.72 | PDE4D (0.39) | KDM4EHPGDMAOBLMNAGAA | |
| SCHEMBL3379763 | 0.71 | TRPM8 (0.39) | GRM5KMT2APDE4BTP53 | |
| SCHEMBL3378478 | 0.69 | DHFR (0.39) | LMNAMEN1NPC1RAB9AKMT2A | |
| SCHEMBL3459398 | 0.69 | SMN1; SMN2 (0.35) | KDM4EHPGDMAOBLMNAGAA | |
| SCHEMBL3377711 | 0.68 | KMT2A (0.40) | GRM2HPGDGRM5NPC1RAB9A | |
| SCHEMBL3377892 | 0.67 | GRM5 (0.57) | KDM4EGAAGRM5NPC1RAB9A | |
| SCHEMBL3380282 | 0.67 | CYP3A4 (0.39) | GRM2MAOBRAB9ACYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |