Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905671 | 0.82 | PDE4D (0.39) | MAOBDHFRLMNARAB9ANPC1 | |
| SCHEMBL3379763 | 0.79 | TRPM8 (0.39) | KMT2A | |
| SCHEMBL3378478 | 0.79 | DHFR (0.39) | DHFRSMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL3459398 | 0.79 | SMN1; SMN2 (0.35) | MAOBDHFRSMN1; SMN2LMNAKMT2A | |
| SCHEMBL3379685 | 0.79 | DPP4 (0.39) | MAOBDHFRSMN1; SMN2LMNAKMT2A | |
| SCHEMBL7931521 | 0.78 | ADORA3 (0.39) | MAOBLMNAMAPTRAB9AKDM4E | |
| SCHEMBL7928996 | 0.76 | GRM2 (0.35) | MAOBLMNAKMT2AMAPTRAB9A | |
| SCHEMBL3377711 | 0.76 | KMT2A (0.40) | SMN1; SMN2KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL3377892 | 0.75 | GRM5 (0.57) | SMN1; SMN2MAPTRAB9ANPC1KDM4E | |
| SCHEMBL3380818 | 0.74 | PDE4D (0.40) | SMN1; SMN2KMT2ANPC1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |