Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12306354 | 0.81 | HTT (0.46) | HTTTP53ALDH1A1MAPTPOLB | |
| SCHEMBL2553715 | 0.74 | ERN1 (0.50) | HTTTP53ERN1ALDH1A1MAPT | |
| SCHEMBL29956412 | 0.73 | ERN1 (0.46) | HTTTP53ERN1ALDH1A1MAPT | |
| SCHEMBL29951605 | 0.73 | ALDH1A1 (0.54) | HTTTP53ERN1ALDH1A1MAPT | |
| SCHEMBL2556619 | 0.72 | ERN1 (0.48) | HTTTP53ERN1ALDH1A1MAPT | |
| SCHEMBL28886073 | 0.72 | ERN1 (0.57) | HTTTP53ERN1ALDH1A1MAPT | |
| SCHEMBL6929818 | 0.72 | ALDH3A1 (0.58) | HTTTP53ERN1ALDH1A1MAPT | |
| SCHEMBL15330430 | 0.71 | ERN1 (0.46) | HTTTP53ERN1ALDH1A1MAPT | |
| SCHEMBL4749290 | 0.70 | ERN1 (0.50) | HTTTP53ERN1ALDH1A1MAPT | |
| SCHEMBL7549386 | 0.69 | MMP14 (0.55) | HTTTP53ERN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010070008-A1 | SUBSTITUTED BICYCLIC IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2010-06-24 | — | — | WO | disclosed |