Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CPT1A | P50416 | 2/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930108 | 0.79 | KMT2A (0.57) | TP53ROCK2ROCK1 | |
| SCHEMBL7927749 | 0.78 | ALDH1A1 (0.57) | MAPTROCK2ROCK1 | |
| SCHEMBL7930156 | 0.73 | HPGD (0.57) | HDAC8HDAC6MAPT | |
| SCHEMBL7929603 | 0.72 | SMYD3 (0.45) | TP53MAPTROCK2ROCK1 | |
| SCHEMBL7928025 | 0.70 | SMPD1 (0.56) | HDAC8HDAC6MAPTROCK2ROCK1 | |
| SCHEMBL7927928 | 0.68 | TP53 (0.49) | TP53MAPT | |
| SCHEMBL7929624 | 0.67 | NR4A2 (0.44) | TP53MAPTROCK2ROCK1 | |
| SCHEMBL8910176 | 0.66 | TDP1 (0.53) | TP53MAPTROCK2ROCK1 | |
| SCHEMBL11818791 | 0.65 | KMT2A (0.52) | TP53 | |
| SCHEMBL19125501 | 0.64 | HDAC6 (0.68) | HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228868-B1 | ANTICARCINOGENIC AND ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-08 | — | — | US | disclosed |