SCHEMBL7930127

SCHEMBL7930127

O=C1CC(Br)C(=O)N1c1cccc(N2C(=O)CC(Br)C2=O)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.50
MEN1 O00255 4/20 0.48
KMT2A Q03164 4/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
MAPT P10636 3/20 0.46
HTT P42858 2/20 0.46
HSP90AA1 P07900 1/20 0.46
CYP2C19 P33261 1/20 0.44
GFER P55789 1/20 0.44
ATM Q13315 1/20 0.44
FAAH O00519 1/20 0.44
MGLL Q99685 1/20 0.44
HPGD P15428 1/20 0.43
CCR6 P51684 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
NLRP1 Q9C000 1/20 0.43
GAA P10253 1/20 0.43
RAB9A P51151 1/20 0.43
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11283819 0.87 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2MAPTGFERGAA
SCHEMBL11755589 0.79 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2L3MBTL1HTTHSP90AA1
SCHEMBL822035 0.78 ALDH1A1 (0.49) ALDH1A1MEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL9825008 0.78 ALDH1A1 (0.53) ALDH1A1MEN1KMT2ASMN1; SMN2MAPT
SCHEMBL9825002 0.76 ALDH1A1 (0.56) ALDH1A1MEN1KMT2AMAPTHTT
SCHEMBL7923850 0.75 FAAH (0.47) ALDH1A1MEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL20846699 0.73 ALDH1A1 (0.59) ALDH1A1MEN1KMT2AMAPTGAA
SCHEMBL13709052 0.73 L3MBTL1 (0.56) ALDH1A1MEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL28123184 0.70 MEN1 (0.59) ALDH1A1MEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL13884938 0.69 ALDH1A1 (0.62) ALDH1A1SMN1; SMN2L3MBTL1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0800551-B1 SULFUR-VULCANIZED RUBBER COMPOSITIONS COMPRISING SUBSTITUTED SUCCINIMIDE COMPOUNDS AKZO NOBEL NV (NL) 2001-06-13 EP disclosed
US-5844049-A Sulfur-vulcanized rubber compositions comprising substituted succinimide compounds AKZO NOBEL NV (NL) 1998-12-01 US disclosed
EP-0800551-A1 SULFUR-VULCANIZED RUBBER COMPOSITIONS COMPRISING SUBSTITUTED SUCCINIMIDE COMPOUNDS Akzo Nobel N.V. (NL) 1997-10-15 EP disclosed
WO-1996020246-A1 SULFUR-VULCANIZED RUBBER COMPOSITIONS COMPRISING SUBSTITUTED SUCCINIMIDE COMPOUNDS AKZO NOBEL N.V. (NL) 1996-07-04 WO disclosed