Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 14/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | TACR2 | P21452 | 4/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654721 | 0.85 | GHSR (0.49) | GHSROPRM1ACE | |
| SCHEMBL8462876 | 0.84 | GHSR (0.39) | GHSROPRM1ACE | |
| Hydrochloric Acid SCHEMBL7575092 | 0.83 | GHSR (0.42) | GHSROPRM1ACETACR1 | |
| SCHEMBL7848280 | 0.78 | GHSR (0.37) | GHSROPRM1ACE | |
| Hydrochloric Acid SCHEMBL7571696 | 0.76 | GHSR (0.37) | GHSRACETACR1 | |
| SCHEMBL8161727 | 0.75 | GHSR (0.39) | GHSRTACR2TACR1 | |
| SCHEMBL7979239 | 0.74 | GHSR (0.39) | GHSRACETACR1 | |
| SCHEMBL8466975 | 0.74 | GHSR (0.39) | GHSRMMP2MMP9TACR1 | |
| SCHEMBL9391064 | 0.74 | GHSR (0.50) | GHSROPRM1ACE | |
| SCHEMBL7401537 | 0.74 | GHSR (0.45) | GHSROPRM1ACEMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011667-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6150352-A | ARYLQUINOLONE ANALOGS | MERCK & CO., INC. (US) | 2000-11-21 | — | — | US | disclosed |
| EP-1011667-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (a New Jersey corp.) (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998055119-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | disclosed |