Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.33 |
| ▸ | POLB | P06746 | 6/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GHSR | Q92847 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957560 | 0.80 | GHSR (0.37) | MAPTMAPK1KMT2AATMNPSR1 | |
| SCHEMBL7931036 | 0.75 | GHSR (0.32) | GHSR | |
| SCHEMBL6220497 | 0.68 | ADAM17 (0.48) | MAPTMAPK1KMT2AATMNPSR1 | |
| SCHEMBL6986484 | 0.68 | ADAM17 (0.48) | MAPTMAPK1KMT2AATMNPSR1 | |
| SCHEMBL6220493 | 0.68 | ADAM17 (0.48) | MAPTMAPK1KMT2AATMNPSR1 | |
| SCHEMBL6220502 | 0.68 | ADAM17 (0.48) | MAPTMAPK1KMT2AATMNPSR1 | |
| SCHEMBL6984686 | 0.68 | ADAM17 (0.48) | MAPTMAPK1KMT2AATMNPSR1 | |
| SCHEMBL6220496 | 0.68 | ADAM17 (0.48) | MAPTMAPK1KMT2AATMNPSR1 | |
| SCHEMBL6982902 | 0.66 | ADAM17 (0.46) | MAPTMAPK1KMT2AATM | |
| SCHEMBL6942351 | 0.65 | HTR2A (0.36) | MAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |