Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MASP2 | O00187 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7931033 | 0.80 | MAPT (0.33) | GHSRKMT2AMAPTATMMAPK1 | |
| SCHEMBL7931036 | 0.74 | GHSR (0.32) | GHSR | |
| SCHEMBL6988956 | 0.73 | HTR2A (0.36) | GHSRHTR2AGRIK1GRIK2LMNA | |
| SCHEMBL6982221 | 0.72 | REN (0.34) | HTR2AKMT2ACTSCMASP2MEN1 | |
| SCHEMBL6986026 | 0.72 | REN (0.33) | HTR2AKMT2ACTSCMASP2MEN1 | |
| SCHEMBL6220493 | 0.72 | ADAM17 (0.48) | HTR2AGRIK1GRIK2KMT2AADAM17 | |
| SCHEMBL6220496 | 0.72 | ADAM17 (0.48) | HTR2AGRIK1GRIK2KMT2AADAM17 | |
| SCHEMBL6984686 | 0.72 | ADAM17 (0.48) | HTR2AGRIK1GRIK2KMT2AADAM17 | |
| SCHEMBL6220502 | 0.72 | ADAM17 (0.48) | HTR2AGRIK1GRIK2KMT2AADAM17 | |
| SCHEMBL6220497 | 0.72 | ADAM17 (0.48) | HTR2AGRIK1GRIK2KMT2AADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |