SCHEMBL7931064

SCHEMBL7931064

CCCOc1ccc(OB(Oc2ccc(OCCC)c(C)c2)Oc2ccc(OCCC)c(C)c2)cc1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 6/20 0.42
ALDH1A1 P00352 4/20 0.41
MAPT P10636 4/20 0.41
KDM4E B2RXH2 3/20 0.41
MEN1 O00255 2/20 0.41
GAA P10253 2/20 0.41
KMT2A Q03164 2/20 0.41
POLB P06746 2/20 0.41
USP2 O75604 1/20 0.41
TP53 P04637 1/20 0.41
CASP1 P29466 1/20 0.41
HTT P42858 1/20 0.41
CASP7 P55210 1/20 0.41
ATM Q13315 1/20 0.41
PTGS1 P23219 1/20 0.39
PTGS2 P35354 1/20 0.39
CSNK2A1 P68400 2/20 0.38
TSHR P16473 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
GPR55 Q9Y2T6 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7934178 0.91 ALDH1A1 (0.39) ESR1ALDH1A1MAPTKDM4EMEN1
SCHEMBL7931065 0.87 ESR1 (0.43) ESR1ALDH1A1MAPTKDM4EMEN1
SCHEMBL7922017 0.86 MAPT (0.44) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL28832127 0.85 PPARG (0.47) ESR1ALDH1A1MAPTKDM4EMEN1
SCHEMBL7922023 0.85 NCF1 (0.38) ESR1ALDH1A1MAPTKDM4EHTT
SCHEMBL1911835 0.82 MTNR1A (0.48) ESR1ALDH1A1MAPTKDM4EMEN1
SCHEMBL7929511 0.81 L3MBTL1 (0.42) ALDH1A1MAPTKDM4EMEN1GAA
SCHEMBL4814773 0.79 ESR1 (0.42) ESR1ALDH1A1MAPTKDM4EMEN1
SCHEMBL7216146 0.79 HTR1A (0.40) ESR1ALDH1A1MAPTKDM4EMEN1
SCHEMBL30630148 0.78 ESR1 (0.54) ESR1ALDH1A1MAPTKDM4EPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140896-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 Takeda Chemical Industries, Ltd. (JP) 2001-10-10 EP disclosed
US-6235771-B1 AIDS THERPAY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
WO-2000037455-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-06-29 WO disclosed