Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | MASP2 | O00187 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7931109 | 0.81 | ADAM17 (0.31) | ADAM17MASP2 | |
| SCHEMBL6942735 | 0.73 | ADAM17 (0.42) | ADAM17HTR2ACTSCGAASMN1; SMN2 | |
| SCHEMBL6942733 | 0.69 | ADAM17 (0.36) | ADAM17GAA | |
| SCHEMBL7930092 | 0.69 | CTSC (0.37) | MASP2HTR2ACTSC | |
| SCHEMBL7930095 | 0.69 | CTSC (0.37) | MASP2HTR2ACTSC | |
| SCHEMBL7930087 | 0.69 | CTSC (0.37) | MASP2HTR2ACTSC | |
| SCHEMBL7930090 | 0.69 | CTSC (0.37) | MASP2HTR2ACTSC | |
| Hydrochloric Acid SCHEMBL6982151 | 0.68 | CTSC (0.35) | ADAM17MASP2HTR2ACTSCGRIK1 | |
| SCHEMBL7957560 | 0.67 | GHSR (0.37) | ADAM17MASP2HTR2ACTSCGRIK1 | |
| SCHEMBL6983320 | 0.67 | ADAM17 (0.37) | ADAM17MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |