Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GALK1 | P51570 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7931279 | 0.97 | DNMT1 (0.36) | DNMT1MAPTRAB9ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL8606301 | 0.87 | DNMT1 (0.41) | DNMT1MAPTRAB9ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL6559419 | 0.78 | MAPT (0.35) | DNMT1MAPTRAB9ASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7940442 | 0.71 | DNMT1 (0.32) | DNMT1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4072322 | 0.70 | DNMT1 (0.42) | DNMT1MAPTRAB9ASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8605086 | 0.68 | DNMT1 (0.41) | DNMT1MAPTRAB9ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL9126330 | 0.68 | MAPT (0.40) | MAPTRAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3919889 | 0.68 | GPR3 (0.46) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7251524 | 0.68 | MYC (0.38) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL4832739 | 0.66 | ALDH1A1 (0.39) | DNMT1MAPTRAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123938-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0672675-A1 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-09-20 | — | — | EP | disclosed |
| US-5451649-A | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-09-19 | — | — | US | disclosed |