Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18699175 | 0.84 | GAA (0.35) | ESR1ESR2SLC6A2KDM4ELMNA | |
| SCHEMBL19910242 | 0.78 | CYP1A2 (0.42) | ESR1ESR2KDM4ELMNACYP3A4 | |
| SCHEMBL23378583 | 0.77 | GPR84 (0.38) | — | |
| SCHEMBL22025156 | 0.76 | ALDH1A1 (0.49) | LMNATSHRSMN1; SMN2 | |
| SCHEMBL681637 | 0.74 | PTGS1 (0.43) | ESR1ESR2KDM4ELMNACYP3A4 | |
| SCHEMBL19003529 | 0.74 | LOXL2 (0.45) | — | |
| SCHEMBL19102080 | 0.73 | UHRF1 (0.41) | ESR1ESR2 | |
| SCHEMBL21398753 | 0.73 | RECQL (0.36) | TSHR | |
| SCHEMBL22457704 | 0.71 | RECQL (0.38) | ESR1ESR2 | |
| SCHEMBL21389727 | 0.71 | NOS2 (0.46) | ESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010075203-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2010-07-01 | — | — | WO | disclosed |