SCHEMBL7933119

SCHEMBL7933119

CC(C)C1=Cc2c(-c3cccc4ccccc34)cccc2C1[Hf](Cl)(Cl)(C1C(C(C)C)=Cc2c(-c3cccc4ccccc34)cccc21)=[Ge](C)C

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.33
NPC1 O15118 1/20 0.31
MAPT P10636 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PTPN1 P18031 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7933102 0.84 KDM4E (0.32)
SCHEMBL7935309 0.84
SCHEMBL27478572 0.83 NPC1 (0.36) ALOX5NPC1MAPTRAB9ASMN1; SMN2
SCHEMBL7935517 0.83 NPC1 (0.31) ALOX5NPC1MAPTRAB9ASMN1; SMN2
SCHEMBL5890213 0.82 NPC1 (0.35) ALOX5NPC1MAPTRAB9ASMN1; SMN2
SCHEMBL7926522 0.81
Hydrochloric Acid SCHEMBL7935519 0.81 NPC1 (0.32) ALOX5NPC1MAPTRAB9ASMN1; SMN2
Hydrochloric Acid SCHEMBL7933124 0.81 ALOX5 (0.34) ALOX5NPC1MAPTRAB9ASMN1; SMN2
SCHEMBL817965 0.79 NPC1 (0.33) NPC1MAPTRAB9ASMN1; SMN2
SCHEMBL5859260 0.77 MAPT (0.36) ALOX5NPC1MAPTRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6184402-B1 RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES CHISSO CORPORATION (JP) 2001-02-06 US disclosed