Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.31 |
| ▸ | MMP2 | P08253 | 3/20 | 0.31 |
| ▸ | MMP9 | P14780 | 3/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
| ▸ | MMP10 | P09238 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983935 | 0.84 | CTSK (0.36) | CTSKTGFBR1P2RX3MMP2MMP9 | |
| SCHEMBL6947398 | 0.75 | ADAM17 (0.34) | CTSKTGFBR1P2RX3MMP2MMP9 | |
| SCHEMBL6937840 | 0.75 | ADAM17 (0.34) | CTSKTGFBR1P2RX3MMP2MMP9 | |
| SCHEMBL8097948 | 0.72 | P2RX3 (0.31) | TGFBR1P2RX3MMP2MMP9ANPEP | |
| SCHEMBL7955132 | 0.72 | ADAM17 (0.44) | APPTGFBR1P2RX3MMP2MMP9 | |
| SCHEMBL7835552 | 0.72 | ADAM17 (0.44) | APPTGFBR1P2RX3MMP2MMP9 | |
| SCHEMBL6946853 | 0.71 | ADAM17 (0.50) | APPTGFBR1P2RX3MMP2MMP9 | |
| SCHEMBL6988246 | 0.71 | ADAM17 (0.43) | APPTGFBR1P2RX3PSEN1PSEN2 | |
| SCHEMBL7934869 | 0.71 | CTSC (0.36) | APPTGFBR1P2RX3MGLL | |
| SCHEMBL6943375 | 0.70 | ADAM17 (0.53) | APPTGFBR1P2RX3PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |