Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928892 | 0.76 | KDM4E (0.49) | ALDH1A1KDM4EHPGDL3MBTL1TDP1 | |
| SCHEMBL5611294 | 0.71 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL7353116 | 0.71 | CRHR1 (0.38) | ALDH1A1KDM4EHPGDCRHR1HSD17B10 | |
| SCHEMBL8122423 | 0.69 | CRHR1 (0.55) | ALDH1A1KDM4EHPGDTDP1CRHR1 | |
| SCHEMBL25151506 | 0.68 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDL3MBTL1TDP1 | |
| SCHEMBL7935049 | 0.67 | CRHR1 (0.47) | L3MBTL1TDP1CRHR1MAPTTP53 | |
| SCHEMBL7937098 | 0.66 | CRHR1 (0.46) | ALDH1A1KDM4EHPGDCRHR1SMN1; SMN2 | |
| SCHEMBL9488025 | 0.66 | LTA4H (0.42) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL5599498 | 0.64 | CRHR1 (0.72) | TDP1CRHR1 | |
| SCHEMBL18717627 | 0.64 | KDM4E (0.75) | ALDH1A1KDM4EHPGDL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248753-B1 | CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONISTS | PFIZER INC | 2001-06-19 | — | — | US | disclosed |
| EP-0765327-B1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER (US) | 1999-07-21 | — | — | EP | disclosed |
| EP-0765327-A1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995034563-A1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER INC. (US) | 1995-12-21 | — | — | WO | disclosed |