Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.50 |
| ▸ | DRD3 | P35462 | 4/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635128 | 0.83 | PLAU (0.45) | DRD2DRD3ADRA1APLAU | |
| SCHEMBL8632417 | 0.83 | PLAU (0.45) | DRD2DRD3ADRA1APLAU | |
| SCHEMBL17155340 | 0.79 | DRD2 (0.50) | DRD2DRD3ADRA1APLAU | |
| SCHEMBL8900426 | 0.76 | HTR1A (0.60) | DRD2DRD3ADRA1A | |
| SCHEMBL17154230 | 0.75 | DRD2 (0.47) | DRD2DRD3ADRA1APLAU | |
| Hydrochloric Acid SCHEMBL9453729 | 0.75 | DRD2 (0.47) | DRD2DRD3ADRA1APLAU | |
| SCHEMBL266921 | 0.74 | DRD2 (0.79) | DRD2DRD3ADRA1A | |
| SCHEMBL4210081 | 0.74 | DRD2 (0.79) | DRD2DRD3ADRA1A | |
| SCHEMBL8076233 | 0.74 | DRD2 (0.79) | DRD2DRD3ADRA1A | |
| SCHEMBL2091729 | 0.74 | LMNA (0.40) | ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331636-B1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, DIABETES, HYPERTENSION, IMPOTENCY, APPETITE CONTROL | THE UPJOHN COMPANY | 2001-12-18 | — | — | US | disclosed |
| US-5545755-A | USEFUL TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS, HYPERTENSION, DIABETES, SEXUAL IMPOTENCY AND TO CONTROL APPETITE | THE UPJOHN COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0476016-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1992-03-25 | — | — | EP | disclosed |
| WO-1990015047-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |