Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | BCHE | P06276 | 6/20 | 0.65 |
| ▸ | ACHE | P22303 | 6/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | GABRP | O00591 | 1/20 | 0.61 |
| ▸ | GABRD | O14764 | 1/20 | 0.61 |
| ▸ | APP | P05067 | 1/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.61 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.61 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945036 | 0.97 | BCHE (0.65) | KMT2ABCHEACHEGABRPGABRD | |
| SCHEMBL7935348 | 0.95 | BCHE (0.66) | KMT2ABCHEACHEGABRPGABRD | |
| SCHEMBL16684277 | 0.81 | ACHE (0.66) | KMT2ABCHEACHEGABRPGABRD | |
| SCHEMBL29522722 | 0.81 | ACHE (0.66) | KMT2ABCHEACHEGABRPGABRD | |
| SCHEMBL8004824 | 0.80 | KMT2A (0.64) | KMT2ABCHEACHEHTTKDM4E | |
| SCHEMBL9208663 | 0.80 | HTT (0.74) | BCHEACHEHTTKDM4EGAA | |
| SCHEMBL13480595 | 0.79 | BCHE (0.76) | BCHEACHEGABRPGABRDAPP | |
| SCHEMBL8473136 | 0.79 | HTT (0.69) | BCHEACHEHTTKDM4EGAA | |
| SCHEMBL8022948 | 0.79 | MEN1 (0.97) | KMT2ABCHEACHEHTTKDM4E | |
| SCHEMBL9748544 | 0.78 | CACNA2D1 (0.63) | KMT2ABCHEACHEGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248750-B1 | CHOLINERGIC FUNCTION AGONISTS FOR MEMORY ENHANCEMENT | HOECHST ROUSSEL PHARMACEUTICALS | 2001-06-19 | — | — | US | claimed |
| US-6075144-A | ABILITY TO INHIBIT ACETYLCHOLINESTERASE; TREATS ALZHEIMER,S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 2000-06-13 | — | — | US | claimed |