Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672163 | 0.97 | MAOA (0.39) | MAOAMAOBACSL1MAPKAPK2HDAC3 | |
| SCHEMBL153179 | 0.97 | MAOA (0.39) | MAOAMAOBACSL1MAPKAPK2HDAC3 | |
| SCHEMBL640816 | 0.97 | MAOA (0.39) | MAOAMAOBACSL1MAPKAPK2HDAC3 | |
| SCHEMBL672205 | 0.97 | MAOA (0.39) | MAOAMAOBACSL1MAPKAPK2HDAC3 | |
| SCHEMBL673859 | 0.97 | MAOA (0.39) | MAOAMAOBACSL1MAPKAPK2HDAC3 | |
| SCHEMBL673696 | 0.97 | MAOA (0.39) | MAOAMAOBACSL1MAPKAPK2HDAC3 | |
| SCHEMBL11607982 | 0.97 | MAOA (0.39) | MAOAMAOBACSL1MAPKAPK2HDAC3 | |
| SCHEMBL4705461 | 0.90 | MAOA (0.43) | MAOAMAOBACSL1HSP90AA1KDM4E | |
| SCHEMBL28807968 | 0.86 | MAOA (0.40) | MAOAMAOBACSL1MAPKAPK2HSP90AA1 | |
| Potassium Ion SCHEMBL167049 | 0.86 | MAOA (0.42) | MAOAMAOBACSL1MAPKAPK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996014841-A1 | ANTIVIRAL AND ANTITUMOR PHARMACEUTICAL COMPOSITIONS | CT-HOLDING S.A. (CH) | 1996-05-23 | — | — | WO | claimed |
| US-4851435-A | CONTAINING ANIONIC ADJUVANT WITH LIPOPHILIC AND HYDROPHILIC GROUPS FOR INCREASED ACTIVITY | MERZ +CO. GMBH & CO. (DE) | 1989-07-25 | — | — | US | claimed |
| CN-109942596-B | Synthesis method of thiolactone | 上海理工大学 | 2022-04-29 | — | — | CN | disclosed |
| EP-0800551-B1 | SULFUR-VULCANIZED RUBBER COMPOSITIONS COMPRISING SUBSTITUTED SUCCINIMIDE COMPOUNDS | AKZO NOBEL NV (NL) | 2001-06-13 | — | — | EP | disclosed |
| US-5844049-A | Sulfur-vulcanized rubber compositions comprising substituted succinimide compounds | AKZO NOBEL NV (NL) | 1998-12-01 | — | — | US | disclosed |
| EP-0800551-A1 | SULFUR-VULCANIZED RUBBER COMPOSITIONS COMPRISING SUBSTITUTED SUCCINIMIDE COMPOUNDS | Akzo Nobel N.V. (NL) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020246-A1 | SULFUR-VULCANIZED RUBBER COMPOSITIONS COMPRISING SUBSTITUTED SUCCINIMIDE COMPOUNDS | AKZO NOBEL N.V. (NL) | 1996-07-04 | — | — | WO | disclosed |
| WO-1996014841-A1 | ANTIVIRAL AND ANTITUMOR PHARMACEUTICAL COMPOSITIONS | CT-HOLDING S.A. (CH) | 1996-05-23 | — | — | WO | disclosed |
| US-4851435-A | CONTAINING ANIONIC ADJUVANT WITH LIPOPHILIC AND HYDROPHILIC GROUPS FOR INCREASED ACTIVITY | MERZ +CO. GMBH & CO. (DE) | 1989-07-25 | — | — | US | disclosed |