Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928746 | 0.90 | DHFR (0.41) | DHFRNPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL7935076 | 0.90 | ESR1 (0.40) | DHFRCYP19A1GSTP1SMN1; SMN2APP | |
| SCHEMBL7928761 | 0.90 | DHFR (0.39) | DHFRALDH1A1CYP19A1GSTP1SMN1; SMN2 | |
| SCHEMBL7937985 | 0.90 | DHFR (0.41) | DHFRCYP19A1GSTP1SMN1; SMN2APP | |
| SCHEMBL7934940 | 0.89 | SMN1; SMN2 (0.45) | MAPTNPC1RAB9AKDM4EMEN1 | |
| SCHEMBL7937975 | 0.88 | MEN1 (0.47) | MAPTNPC1RAB9AKDM4EMEN1 | |
| SCHEMBL7940249 | 0.85 | SMN1; SMN2 (0.52) | MAPTKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL7189972 | 0.85 | MAPT (0.44) | MAPTNPC1RAB9AALDH1A1RAD52 | |
| SCHEMBL7937708 | 0.81 | SMN1; SMN2 (0.45) | CYP19A1SMN1; SMN2APPRELA | |
| SCHEMBL3115783 | 0.80 | PTGS2 (0.56) | MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |