Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928761 | 0.91 | DHFR (0.39) | DHFRCYP19A1APPGSTP1SMN1; SMN2 | |
| SCHEMBL7937022 | 0.90 | MAPT (0.44) | DHFRCYP19A1APPGSTP1SMN1; SMN2 | |
| SCHEMBL7935041 | 0.89 | ADORA2A (0.45) | ADORA2AADORA1PTGS2PTGS1CYP1A2 | |
| SCHEMBL7928746 | 0.86 | DHFR (0.41) | DHFRCYP19A1APPGSTP1SMN1; SMN2 | |
| SCHEMBL7190071 | 0.86 | GSTP1 (0.39) | DHFRGSTP1PTGS2PTGS1CYP1A2 | |
| SCHEMBL7934940 | 0.85 | SMN1; SMN2 (0.45) | APPGSTP1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL7935076 | 0.84 | ESR1 (0.40) | DHFRCYP19A1APPGSTP1SMN1; SMN2 | |
| SCHEMBL7940253 | 0.84 | TLR9 (0.44) | CYP19A1APPSMN1; SMN2PTGS2CYP1A2 | |
| SCHEMBL7937708 | 0.83 | SMN1; SMN2 (0.45) | CYP19A1APPSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL7940249 | 0.82 | SMN1; SMN2 (0.52) | ADORA2AADORA1CYP19A1APPGSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |