Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.32 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7627498 | 0.72 | EDNRB (0.30) | — | |
| SCHEMBL4455072 | 0.65 | CALM1 (0.50) | CALM1LTA4H | |
| SCHEMBL29675199 | 0.65 | CALM1 (0.50) | CALM1LTA4H | |
| SCHEMBL146770 | 0.65 | CALM1 (0.50) | CALM1LTA4HCYP3A4CYP2D6TSHR | |
| SCHEMBL29675106 | 0.65 | CALM1 (0.50) | CALM1LTA4HCYP3A4CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL27496565 | 0.64 | CYP3A4 (0.34) | CNR2GPR55CALM1CYP3A4CYP2D6 | |
| SCHEMBL2140995 | 0.63 | CALM1 (0.57) | CALM1LTA4HCYP3A4CYP2D6TSHR | |
| SCHEMBL3304087 | 0.61 | CALM1 (0.55) | CALM1LTA4HCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11427143 | 0.61 | BCL2 (0.50) | CNR2GPR55 | |
| SCHEMBL8087746 | 0.61 | BCL2 (0.45) | CALM1LTA4HCYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751156-B1 | Ethylene copolymer rubber, vulcanizable rubber composition containing the copolymer rubber, and process for preparing the copolymer rubber | MITSUI CHEMICALS INC (JP) | 2001-09-05 | — | — | EP | disclosed |