Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937733 | 0.91 | MAPT (0.43) | ABCG2ABCB1ABCC1MAPTMAPK1 | |
| SCHEMBL7937717 | 0.86 | ABCG2 (0.49) | ABCG2MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL7937975 | 0.83 | MEN1 (0.47) | ABCG2ABCB1ABCC1MAPTALDH1A1 | |
| SCHEMBL7940260 | 0.81 | TLR9 (0.42) | MAPTMAPK1NPSR1ADORA3ADORA2A | |
| SCHEMBL7940195 | 0.80 | HSPB1 (0.46) | MAPTMAPK1MEN1KMT2ACYP19A1 | |
| SCHEMBL7940253 | 0.80 | TLR9 (0.44) | MAPTMAPK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9703810 | 0.78 | HSPB1 (0.48) | MAPTMAPK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL7937836 | 0.78 | APP (0.48) | MAPTMAPK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL7928854 | 0.78 | MAOB (0.47) | ABCG2ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL7937164 | 0.76 | MTNR1B (0.47) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |