Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937699 | 0.91 | ABCG2 (0.49) | MAPTSMN1; SMN2NPC1RAB9APTGS2 | |
| SCHEMBL7940253 | 0.90 | TLR9 (0.44) | MAPTHPGDSMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL7935041 | 0.84 | ADORA2A (0.45) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7937717 | 0.83 | ABCG2 (0.49) | MAPTHPGDSMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL7940260 | 0.82 | TLR9 (0.42) | MAPTHPGDPTGS2PDE7AADORA3 | |
| SCHEMBL8496759 | 0.79 | ALDH1A1 (0.39) | NPC1RAB9APTGS2PTGS1LMNA | |
| SCHEMBL7182545 | 0.79 | ESR1 (0.52) | HPGDSMN1; SMN2ABCG2ALDH1A1KDM4E | |
| SCHEMBL7182554 | 0.79 | ESR1 (0.52) | HPGDSMN1; SMN2ABCG2ALDH1A1KDM4E | |
| SCHEMBL8499012 | 0.78 | NPBWR1 (0.40) | PTGS2PTGS1ADORA2ANPBWR1ALDH1A1 | |
| SCHEMBL7940195 | 0.78 | HSPB1 (0.46) | MAPTPTGS2PTGS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |