Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940260 | 0.93 | TLR9 (0.42) | TLR9PDE7AMAPTHPGDHNF4A | |
| SCHEMBL7937733 | 0.90 | MAPT (0.43) | PDE7AMAPTHPGDMEN1KMT2A | |
| SCHEMBL7940195 | 0.88 | HSPB1 (0.46) | TLR9MAPTHNF4AMEN1KMT2A | |
| SCHEMBL7937836 | 0.87 | APP (0.48) | TLR9MAPTHPGDHNF4AMEN1 | |
| SCHEMBL7935034 | 0.84 | PLAU (0.40) | TLR9MAPTHPGDHNF4AKMT2A | |
| SCHEMBL7928854 | 0.84 | MAOB (0.47) | TLR9HNF4AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7937985 | 0.84 | DHFR (0.41) | SMN1; SMN2APPCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7190071 | 0.83 | GSTP1 (0.39) | MAPTHPGDNPC1CYP1A2RAB9A | |
| SCHEMBL3121428 | 0.81 | PTGS2 (0.53) | HNF4AAPPPTGS2 | |
| SCHEMBL3111379 | 0.81 | PIK3CA (0.42) | TLR9MAPTHNF4AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |