Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.33 |
| ▸ | CTSL | P07711 | 11/20 | 0.33 |
| ▸ | CTSS | P25774 | 8/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.31 |
| ▸ | CTSB | P07858 | 2/20 | 0.31 |
| ▸ | CTSV | O60911 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947540 | 0.76 | CTSK (0.33) | CTSKCTSLCTSSLMNAGAA | |
| SCHEMBL6940316 | 0.67 | TAS1R3 (0.37) | CTSKCTSSLMNAGAAMAPK1 | |
| SCHEMBL20425403 | 0.59 | MAOB (0.44) | LMNAMAPK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL10511538 | 0.54 | MAOB (0.46) | MAPK1RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL19387376 | 0.54 | ALDH1A1 (0.76) | LMNARAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL6417131 | 0.53 | RAB9A (0.58) | LMNAMAPK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL16544798 | 0.53 | TAS1R3 (0.56) | LMNAGAAMAPK1RAB9ANPC1 | |
| SCHEMBL20425436 | 0.53 | ALDH1A1 (0.47) | LMNAMAPK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL18768462 | 0.53 | KDM4E (0.50) | LMNAGAARAB9ANPC1ALDH1A1 | |
| SCHEMBL18851814 | 0.53 | RAB9A (0.62) | CTSKLMNARAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |