Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 6/20 | 0.32 |
| ▸ | CTSL | P07711 | 6/20 | 0.32 |
| ▸ | CTSB | P07858 | 4/20 | 0.32 |
| ▸ | CTSV | O60911 | 2/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940316 | 0.83 | TAS1R3 (0.37) | CTSKRAB9ATAS1R3TAS1R1CTSS | |
| SCHEMBL6944675 | 0.78 | — | — | |
| SCHEMBL6942309 | 0.78 | MMP2 (0.31) | CTSLCTSBMMP2 | |
| SCHEMBL6945566 | 0.77 | KDM4E (0.33) | P2RX3LMNAMMP2KDM4E | |
| SCHEMBL8111706 | 0.77 | ADAM17 (0.33) | P2RX3GAAMMP2ALDH1A1 | |
| SCHEMBL6945140 | 0.77 | — | — | |
| SCHEMBL6943556 | 0.77 | ADAM17 (0.33) | P2RX3GAAMMP2ALDH1A1 | |
| SCHEMBL6942209 | 0.77 | ADAM17 (0.33) | P2RX3GAAMMP2ALDH1A1 | |
| SCHEMBL6944369 | 0.76 | P2RX3 (0.36) | P2RX3 | |
| SCHEMBL7937844 | 0.76 | CTSK (0.33) | CTSKRAB9ATAS1R3TAS1R1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |