Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL794272 | 0.95 | PHGDH (0.43) | TRPV3KDRHTR2AHTR2CNOTUM | |
| SCHEMBL798794 | 0.84 | HRH3 (0.40) | KDRHTR2AHTR2CJAK2SRC | |
| SCHEMBL793437 | 0.82 | CYP17A1 (0.50) | HTR2AHTR2C | |
| SCHEMBL798654 | 0.81 | PDGFRB (0.43) | KDRPDGFRB | |
| SCHEMBL793143 | 0.81 | GRIN2D (0.42) | KDRPDGFRB | |
| SCHEMBL798533 | 0.79 | TIPARP (0.46) | KDRPDGFRBSCN9A | |
| SCHEMBL793474 | 0.76 | CYP11B2 (0.41) | KDRHTR2AHTR2CPDGFRBPDE10A | |
| SCHEMBL793461 | 0.75 | CYP11B2 (0.43) | HTR2AHTR2CNOTUMJAK2SRC | |
| SCHEMBL12065737 | 0.75 | TRPV3 (0.39) | TRPV3KDRNOTUMPHGDHSPR | |
| SCHEMBL793449 | 0.75 | PARP1 (0.42) | HTR2AHTR2CNOTUMJAK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627648-A1 | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS | Novartis AG (CH) | 2013-08-21 | — | — | EP | claimed |
| WO-2012035078-A1 | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | claimed |