Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | DRD1 | P21728 | 6/20 | 0.40 |
| ▸ | DRD5 | P21918 | 5/20 | 0.40 |
| ▸ | DRD3 | P35462 | 5/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL793143 | 0.84 | GRIN2D (0.42) | PDGFRBKDRCYP11B1CYP11B2EED | |
| SCHEMBL798146 | 0.84 | DRD1 (0.42) | PDGFRBKDRDRD2DRD1DRD5 | |
| SCHEMBL798533 | 0.82 | TIPARP (0.46) | PDGFRBKDRDRD2DRD1DRD5 | |
| SCHEMBL793875 | 0.81 | TRPV3 (0.41) | PDGFRBKDR | |
| SCHEMBL793474 | 0.79 | CYP11B2 (0.41) | PDGFRBKDRCYP11B1CYP11B2 | |
| SCHEMBL793623 | 0.77 | MAPT (0.52) | — | |
| SCHEMBL794272 | 0.76 | PHGDH (0.43) | PDGFRBKDR | |
| SCHEMBL5518917 | 0.75 | DRD1 (0.50) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL793106 | 0.73 | CYP11B2 (0.48) | ESR1ESR2CYP11B1CYP11B2 | |
| SCHEMBL793768 | 0.73 | CYP11B2 (0.41) | ESR1ESR2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627648-A1 | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS | Novartis AG (CH) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012035078-A1 | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |