Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 3/20 | 0.38 |
| ▸ | CASP7 | P55210 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
| ▸ | PPIA | P62937 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7931277 | 0.74 | ALDH1A1 (0.39) | ALDH1A1HSD17B10TP53HPGDCASP1 | |
| SCHEMBL17230347 | 0.71 | ALDH1A1 (0.48) | ALDH1A1HSD17B10TP53HPGDCASP1 | |
| Hydrochloric Acid SCHEMBL618216 | 0.70 | GPR3 (0.42) | TSHRMEN1KMT2APOLBCYP2D6 | |
| Hydrochloric Acid SCHEMBL8378993 | 0.69 | GPR3 (0.41) | TSHRMEN1KMT2APOLBCYP2D6 | |
| Hydrochloric Acid SCHEMBL8599251 | 0.69 | GPR3 (0.41) | TSHRMEN1KMT2APOLBCYP2D6 | |
| SCHEMBL1811522 | 0.68 | ALDH1A1 (0.67) | ALDH1A1HSD17B10TP53HPGDCASP1 | |
| SCHEMBL28763536 | 0.68 | ALDH1A1 (0.67) | ALDH1A1HSD17B10TP53HPGDCASP1 | |
| SCHEMBL9042905 | 0.68 | ALDH1A1 (0.67) | ALDH1A1HSD17B10TP53HPGDCASP1 | |
| SCHEMBL1154675 | 0.68 | ALDH1A1 (0.67) | ALDH1A1HSD17B10TP53HPGDCASP1 | |
| SCHEMBL5917389 | 0.68 | ALDH1A1 (0.67) | ALDH1A1HSD17B10TP53HPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123938-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 2001-08-16 | — | — | EP | disclosed |
| US-5451649-A | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-09-19 | — | — | US | disclosed |