Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.35 |
| ▸ | REN | P00797 | 3/20 | 0.34 |
| ▸ | MMP2 | P08253 | 7/20 | 0.33 |
| ▸ | MMP3 | P08254 | 6/20 | 0.33 |
| ▸ | MMP7 | P09237 | 5/20 | 0.33 |
| ▸ | MMP1 | P03956 | 7/20 | 0.33 |
| ▸ | MMP8 | P22894 | 3/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940910 | 0.88 | ADAM17 (0.67) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL7935009 | 0.82 | ADAM17 (0.76) | ADAM17PSMB5RENMMP1MMP9 | |
| SCHEMBL6941589 | 0.82 | ADAM17 (0.49) | ADAM17PSMB5MMP2MMP3MMP7 | |
| SCHEMBL6945362 | 0.81 | ADAM17 (0.54) | ADAM17PSMB5MMP1MMP9MMP13 | |
| SCHEMBL6939553 | 0.80 | ADAM17 (0.51) | ADAM17PSMB5MMP2MMP3MMP7 | |
| SCHEMBL6948147 | 0.79 | ADAM17 (0.55) | ADAM17ALDH1A1 | |
| SCHEMBL6948137 | 0.79 | ADAM17 (0.55) | ADAM17ALDH1A1 | |
| SCHEMBL6945274 | 0.79 | ADAM17 (0.47) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6220502 | 0.79 | ADAM17 (0.48) | ADAM17RENMAPTATMALDH1A1 | |
| SCHEMBL6220496 | 0.79 | ADAM17 (0.48) | ADAM17RENMAPTATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |