Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 6/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | MMP13 | P45452 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940364 | 0.88 | ADAM17 (0.70) | ADAM17MMP1MMP13MMP9 | |
| SCHEMBL7935009 | 0.84 | ADAM17 (0.76) | ADAM17PSMB5MMP1MMP13MMP9 | |
| SCHEMBL6941589 | 0.82 | ADAM17 (0.49) | ADAM17PSMB5MMP1 | |
| SCHEMBL7940342 | 0.81 | ADAM17 (0.52) | ADAM17PSMB5NPSR1MMP1MMP13 | |
| SCHEMBL6948147 | 0.79 | ADAM17 (0.55) | ADAM17GRIK1GRIK2 | |
| SCHEMBL6948137 | 0.79 | ADAM17 (0.55) | ADAM17GRIK1GRIK2 | |
| SCHEMBL6942217 | 0.79 | ADAM17 (0.49) | ADAM17 | |
| SCHEMBL6220493 | 0.79 | ADAM17 (0.48) | ADAM17MEN1MAPK1KMT2ANPSR1 | |
| SCHEMBL6984686 | 0.79 | ADAM17 (0.48) | ADAM17MEN1MAPK1KMT2ANPSR1 | |
| SCHEMBL6220496 | 0.79 | ADAM17 (0.48) | ADAM17MEN1MAPK1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |