SCHEMBL6941589

SCHEMBL6941589

CC(C)C[C@@H](C(=O)NN(c1ccccc1)S(C)(=O)=O)C(CC=Cc1cccnc1)C(=O)OC(C)(C)C

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADAM17 P78536 4/20 0.49
CHRNB2 P17787 1/20 0.40
CHRNA4 P43681 1/20 0.40
RAB9A P51151 2/20 0.35
MMP1 P03956 1/20 0.34
MMP2 P08253 1/20 0.34
MMP3 P08254 1/20 0.34
MMP7 P09237 1/20 0.34
NAMPT P43490 5/20 0.33
POLB P06746 1/20 0.33
GAA P10253 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
TBXAS1 P24557 1/20 0.33
PSMB5 P28074 1/20 0.33
NPC1 O15118 1/20 0.32
ALOX5 P09917 2/20 0.32
PTGS1 P23219 1/20 0.32
PTGS2 P35354 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6942218 0.89 ADAM17 (0.54) ADAM17CHRNB2CHRNA4RAB9AMMP1
SCHEMBL6943011 0.88 ADAM17 (0.65) ADAM17CHRNB2CHRNA4MMP1MMP2
SCHEMBL6945362 0.82 ADAM17 (0.54) ADAM17MMP1PSMB5
SCHEMBL7940342 0.82 ADAM17 (0.52) ADAM17MMP1MMP2MMP3MMP7
SCHEMBL6944742 0.82 CHRNB2 (0.43) ADAM17CHRNB2CHRNA4RAB9AMMP1
SCHEMBL6943306 0.81 ADAM17 (0.45) ADAM17CHRNB2CHRNA4MMP1MMP2
SCHEMBL7935009 0.80 ADAM17 (0.76) ADAM17MMP1PSMB5
SCHEMBL6982398 0.80 CHRNB2 (0.45) ADAM17CHRNB2CHRNA4RAB9AMMP1
SCHEMBL6940945 0.79 ADAM17 (0.75) ADAM17MMP1MMP2MMP3MMP7
SCHEMBL6939576 0.79 ADAM17 (0.40) ADAM17MMP1POLBPSMB5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0993442-B1 HYDRAZINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2003-04-23 EP disclosed
US-6235787-B1 ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS HOFFMANN-LA ROCHE INC. 2001-05-22 US disclosed