Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10200897 | 0.82 | PLA2G7 (0.39) | TP53MDM2PLA2G7ALOX5APFEN1 | |
| SCHEMBL7943764 | 0.81 | TNF (0.41) | TP53MDM2PLA2G7ALOX5APFEN1 | |
| SCHEMBL10200896 | 0.77 | PLA2G7 (0.38) | TP53MDM2PLA2G7ALOX5APFEN1 | |
| SCHEMBL5579942 | 0.70 | MAPT (0.42) | ALOX5APFEN1 | |
| SCHEMBL31163151 | 0.70 | GPR84 (0.40) | ALOX5APFEN1DGAT1 | |
| SCHEMBL7941395 | 0.69 | AKR1B1 (0.36) | TP53AKR1B1 | |
| SCHEMBL31162985 | 0.68 | MAPT (0.39) | ALOX5APFEN1DGAT1 | |
| SCHEMBL2131444 | 0.67 | CYP11B1 (0.44) | PLA2G7 | |
| SCHEMBL4678900 | 0.67 | ALOX5AP (0.36) | ALOX5APFEN1DGAT1 | |
| SCHEMBL30442588 | 0.65 | LMNA (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054278-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |