Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | AKR1A1 | P14550 | 3/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10200896 | 0.81 | PLA2G7 (0.38) | MEN1KMT2ALMNATP53MDM2 | |
| SCHEMBL7940802 | 0.81 | TP53 (0.34) | AKR1B1TP53MDM2ALOX5APFEN1 | |
| SCHEMBL1970646 | 0.77 | LMNA (0.59) | TNFLMNAAKR1A1AKR1B1PTGER3 | |
| SCHEMBL1093500 | 0.73 | LMNA (0.43) | TNFMEN1KMT2ALMNAAKR1A1 | |
| SCHEMBL10200897 | 0.73 | PLA2G7 (0.39) | TP53MDM2ALOX5APFEN1PLA2G7 | |
| SCHEMBL31163151 | 0.72 | GPR84 (0.40) | LMNAALOX5APFEN1 | |
| SCHEMBL20135344 | 0.70 | AKR1B1 (0.44) | TNFLMNAAKR1A1AKR1B1PTGER3 | |
| SCHEMBL5579942 | 0.69 | MAPT (0.42) | MEN1KMT2ALMNAALOX5APFEN1 | |
| SCHEMBL31162985 | 0.69 | MAPT (0.39) | MEN1KMT2AALOX5APFEN1 | |
| SCHEMBL2131444 | 0.69 | CYP11B1 (0.44) | PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054278-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |