Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | EIF4E | P06730 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7813292 | 0.74 | DHFR (0.56) | TYMSDHFRMEN1LMNAKMT2A | |
| SCHEMBL7813638 | 0.73 | TYMS (0.60) | TYMSDHFRMEN1KMT2AL3MBTL1 | |
| SCHEMBL28021120 | 0.68 | PNP (0.70) | TYMSDHFRMEN1LMNAKMT2A | |
| Bromide SCHEMBL7806174 | 0.68 | MEN1 (0.37) | TYMSDHFREIF4EMEN1LMNA | |
| SCHEMBL7813634 | 0.63 | MEN1 (0.45) | TYMSDHFRMEN1LMNAKMT2A | |
| Bromide SCHEMBL7940869 | 0.63 | MEN1 (0.44) | TYMSDHFRMEN1LMNAKMT2A | |
| SCHEMBL8673113 | 0.61 | MEN1 (0.58) | TYMSDHFRMEN1LMNAKMT2A | |
| SCHEMBL30072053 | 0.59 | LMNA (0.56) | MEN1LMNAKMT2A | |
| SCHEMBL16028279 | 0.59 | TYMS (0.53) | TYMSEIF4ELMNAKMT2A | |
| SCHEMBL23296136 | 0.58 | DBH (0.54) | MEN1LMNAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245910-B1 | Process for producing purine derivatives | AJINOMOTO CO., INC. (JP) | 2001-06-12 | — | — | US | disclosed |