Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 16/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 14/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7941769 | 0.79 | POLB (0.54) | NPC1RAB9APKMSMN1; SMN2MAPT | |
| SCHEMBL7942303 | 0.78 | NPC1 (0.53) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL7933157 | 0.76 | MAPT (0.52) | MEN1NPC1RAB9AKMT2APKM | |
| SCHEMBL7940427 | 0.76 | SMN1; SMN2 (0.48) | MEN1NPC1RAB9AKMT2AGRM4 | |
| SCHEMBL7942653 | 0.73 | BACE1 (0.46) | NPC1RAB9AGRM4SMN1; SMN2 | |
| SCHEMBL7942651 | 0.72 | BACE1 (0.47) | NPC1RAB9ASMN1; SMN2CYP2C9 | |
| SCHEMBL7943391 | 0.71 | MEN1 (0.46) | MEN1NPC1RAB9AKMT2APKM | |
| SCHEMBL8027585 | 0.71 | MPO (0.50) | RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7933959 | 0.70 | BACE1 (0.48) | — | |
| SCHEMBL12225791 | 0.69 | SMN1; SMN2 (0.68) | MEN1NPC1RAB9AKMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |